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Deuteration versus ethylation – strategies to improve the metabolic fate of an (18)F-labeled celecoxib derivative

The inducible isoenzyme cyclooxygenase-2 (COX-2) is closely associated with chemo-/radioresistance and poor prognosis of solid tumors. Therefore, COX-2 represents an attractive target for functional characterization of tumors by positron emission tomography (PET). In this study, the celecoxib deriva...

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Detalles Bibliográficos
Autores principales:	Laube, Markus, Gassner, Cemena, Neuber, Christin, Wodtke, Robert, Ullrich, Martin, Haase-Kohn, Cathleen, Löser, Reik, Köckerling, Martin, Kopka, Klaus, Kniess, Torsten, Hey-Hawkins, Evamarie, Pietzsch, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057277/ https://www.ncbi.nlm.nih.gov/pubmed/35517533 http://dx.doi.org/10.1039/d0ra04494f

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