Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides

An efficient and highly diastereoselective synthesis of CF(3)-dihydrobenzofurans by the reaction of in situ-generated CF(3)-oQMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresp...

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Autores principales: Jha, Babli K., Prudhviraj, Jaggaraju, Mainkar, Prathama S., Punna, Nagender, Chandrasekhar, Srivari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057278/
https://www.ncbi.nlm.nih.gov/pubmed/35517513
http://dx.doi.org/10.1039/d0ra08289a
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author Jha, Babli K.
Prudhviraj, Jaggaraju
Mainkar, Prathama S.
Punna, Nagender
Chandrasekhar, Srivari
author_facet Jha, Babli K.
Prudhviraj, Jaggaraju
Mainkar, Prathama S.
Punna, Nagender
Chandrasekhar, Srivari
author_sort Jha, Babli K.
collection PubMed
description An efficient and highly diastereoselective synthesis of CF(3)-dihydrobenzofurans by the reaction of in situ-generated CF(3)-oQMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF(3)-oQM has been utilized first time for the annulation reaction.
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spelling pubmed-90572782022-05-04 Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides Jha, Babli K. Prudhviraj, Jaggaraju Mainkar, Prathama S. Punna, Nagender Chandrasekhar, Srivari RSC Adv Chemistry An efficient and highly diastereoselective synthesis of CF(3)-dihydrobenzofurans by the reaction of in situ-generated CF(3)-oQMs in the presence of a base with sulphur ylides is put forward. The generality of the present developed method was well studied with diverse substrates to access the corresponding products in excellent yields. The highly reactive CF(3)-oQM has been utilized first time for the annulation reaction. The Royal Society of Chemistry 2020-10-20 /pmc/articles/PMC9057278/ /pubmed/35517513 http://dx.doi.org/10.1039/d0ra08289a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jha, Babli K.
Prudhviraj, Jaggaraju
Mainkar, Prathama S.
Punna, Nagender
Chandrasekhar, Srivari
Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title_full Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title_fullStr Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title_full_unstemmed Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title_short Diastereoselective synthesis of CF(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated CF(3)-o-quinone methides and sulfur ylides
title_sort diastereoselective synthesis of cf(3)-dihydrobenzofurans by [4+1] annulation of in situ-generated cf(3)-o-quinone methides and sulfur ylides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057278/
https://www.ncbi.nlm.nih.gov/pubmed/35517513
http://dx.doi.org/10.1039/d0ra08289a
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