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Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies

The properties of nanomaterials generated by external stimuli are considered an innovative and promising replacement for the annihilation of bacterial infectious diseases. The present study demonstrates the possibility of getting the antibiotic-like drug action from our newly synthesized nanohybrid...

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Autores principales: Hasan, Md. Nur, Maji, Tuhin Kumar, Pal, Uttam, Bera, Arpan, Bagchi, Damayanti, Halder, Animesh, Ahmed, Saleh A., Al-Fahemi, Jabir H., Bawazeer, Tahani M., Saha-Dasgupta, Tanusri, Pal, Samir Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057326/
https://www.ncbi.nlm.nih.gov/pubmed/35518422
http://dx.doi.org/10.1039/d0ra07441a
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author Hasan, Md. Nur
Maji, Tuhin Kumar
Pal, Uttam
Bera, Arpan
Bagchi, Damayanti
Halder, Animesh
Ahmed, Saleh A.
Al-Fahemi, Jabir H.
Bawazeer, Tahani M.
Saha-Dasgupta, Tanusri
Pal, Samir Kumar
author_facet Hasan, Md. Nur
Maji, Tuhin Kumar
Pal, Uttam
Bera, Arpan
Bagchi, Damayanti
Halder, Animesh
Ahmed, Saleh A.
Al-Fahemi, Jabir H.
Bawazeer, Tahani M.
Saha-Dasgupta, Tanusri
Pal, Samir Kumar
author_sort Hasan, Md. Nur
collection PubMed
description The properties of nanomaterials generated by external stimuli are considered an innovative and promising replacement for the annihilation of bacterial infectious diseases. The present study demonstrates the possibility of getting the antibiotic-like drug action from our newly synthesized nanohybrid (NH), which consists of norfloxacin (NF) as the photosensitive material covalently attached to the ZnO nanoparticle (NP). The synthesized NH has been characterized using various microscopic and spectroscopic techniques. Steady state fluorescence and time-correlated single photon counting (TCSPC)-based spectroscopic studies demonstrate the efficient electron transfer from NF to ZnO. This enhances the reactive oxygen species (ROS) production capability of the system. First principles density functional theory has been calculated to gain insight into the charge separation mechanism. To explore the electron densities of the occupied and unoccupied levels of NH, we have verified the nature of the electronic structure. It is observed that there is a very high possibility of electron transfer from NF to ZnO in the NH system, which validates the experimental findings. Finally, the efficacy of NH compared to NF and ZnO has been estimated on the in vitro culture of E. coli bacteria. We have obtained a significant reduction in the bacterial viability by NH with respect to control in the presence of light. These results suggest that the synthesized NH could be a potential candidate in the new generation alternative antibacterial drugs. Overall, the study depicts a detailed physical insight for nanohybrid systems that can be beneficial for manifold application purposes.
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spelling pubmed-90573262022-05-04 Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies Hasan, Md. Nur Maji, Tuhin Kumar Pal, Uttam Bera, Arpan Bagchi, Damayanti Halder, Animesh Ahmed, Saleh A. Al-Fahemi, Jabir H. Bawazeer, Tahani M. Saha-Dasgupta, Tanusri Pal, Samir Kumar RSC Adv Chemistry The properties of nanomaterials generated by external stimuli are considered an innovative and promising replacement for the annihilation of bacterial infectious diseases. The present study demonstrates the possibility of getting the antibiotic-like drug action from our newly synthesized nanohybrid (NH), which consists of norfloxacin (NF) as the photosensitive material covalently attached to the ZnO nanoparticle (NP). The synthesized NH has been characterized using various microscopic and spectroscopic techniques. Steady state fluorescence and time-correlated single photon counting (TCSPC)-based spectroscopic studies demonstrate the efficient electron transfer from NF to ZnO. This enhances the reactive oxygen species (ROS) production capability of the system. First principles density functional theory has been calculated to gain insight into the charge separation mechanism. To explore the electron densities of the occupied and unoccupied levels of NH, we have verified the nature of the electronic structure. It is observed that there is a very high possibility of electron transfer from NF to ZnO in the NH system, which validates the experimental findings. Finally, the efficacy of NH compared to NF and ZnO has been estimated on the in vitro culture of E. coli bacteria. We have obtained a significant reduction in the bacterial viability by NH with respect to control in the presence of light. These results suggest that the synthesized NH could be a potential candidate in the new generation alternative antibacterial drugs. Overall, the study depicts a detailed physical insight for nanohybrid systems that can be beneficial for manifold application purposes. The Royal Society of Chemistry 2020-10-23 /pmc/articles/PMC9057326/ /pubmed/35518422 http://dx.doi.org/10.1039/d0ra07441a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hasan, Md. Nur
Maji, Tuhin Kumar
Pal, Uttam
Bera, Arpan
Bagchi, Damayanti
Halder, Animesh
Ahmed, Saleh A.
Al-Fahemi, Jabir H.
Bawazeer, Tahani M.
Saha-Dasgupta, Tanusri
Pal, Samir Kumar
Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title_full Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title_fullStr Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title_full_unstemmed Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title_short Wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
title_sort wide bandgap semiconductor-based novel nanohybrid for potential antibacterial activity: ultrafast spectroscopy and computational studies
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057326/
https://www.ncbi.nlm.nih.gov/pubmed/35518422
http://dx.doi.org/10.1039/d0ra07441a
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