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pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia
In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057345/ https://www.ncbi.nlm.nih.gov/pubmed/35518395 http://dx.doi.org/10.1039/d0ra06916g |
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author | Keshavarz, Hasan Khavandi, Alireza Alamolhoda, Somaye Naimi-Jamal, M. Reza |
author_facet | Keshavarz, Hasan Khavandi, Alireza Alamolhoda, Somaye Naimi-Jamal, M. Reza |
author_sort | Keshavarz, Hasan |
collection | PubMed |
description | In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/T = 37 °C (simulating physiological condition) and pH 5/T = 43 °C (pH simulating endosomes/hyperthermia) were 15 and 70%, respectively, so, drug release was increased with hyperthermia. To determine the biocompatibility of the nanogels, an MTT assay of L929 cells was performed for 24, 48 and 72 h. The results show high biocompatibility of nanogels even at high concentrations (over 80% cell viability after 72 h for all concentrations). |
format | Online Article Text |
id | pubmed-9057345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90573452022-05-04 pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia Keshavarz, Hasan Khavandi, Alireza Alamolhoda, Somaye Naimi-Jamal, M. Reza RSC Adv Chemistry In clinical applications, chemotherapy and hyperthermia are commonly used together. To achieve this, we synthesized multifunctional magnetite mesoporous silica nanoparticles (MMSNs) coated with a chitosan hydrogel. pH-Responsive chitosan hydrogels (cross-linked glutaraldehyde) were used to cover mesoporous silica pores. The infrared spectroscopy (FT-IR) and electron microscopy images (SEM and TEM) confirm that a hydrogel layer and a silica shell were formed. By applying alternating magnetic fields (AMF) to nanogels, heat generation (43 °C) occurred within a short time. The drug release (tamoxifen) of nanogels was studied for 72 h at different pH and temperatures. Drug release at pH 7.4/T = 37 °C (simulating physiological condition) and pH 5/T = 43 °C (pH simulating endosomes/hyperthermia) were 15 and 70%, respectively, so, drug release was increased with hyperthermia. To determine the biocompatibility of the nanogels, an MTT assay of L929 cells was performed for 24, 48 and 72 h. The results show high biocompatibility of nanogels even at high concentrations (over 80% cell viability after 72 h for all concentrations). The Royal Society of Chemistry 2020-10-23 /pmc/articles/PMC9057345/ /pubmed/35518395 http://dx.doi.org/10.1039/d0ra06916g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Keshavarz, Hasan Khavandi, Alireza Alamolhoda, Somaye Naimi-Jamal, M. Reza pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title | pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title_full | pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title_fullStr | pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title_full_unstemmed | pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title_short | pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
title_sort | ph-sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057345/ https://www.ncbi.nlm.nih.gov/pubmed/35518395 http://dx.doi.org/10.1039/d0ra06916g |
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