Homo-condensation of acetophenones toward imidazothiones

Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, tr...

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Detalles Bibliográficos
Autores principales: Pham, Phuc Hoang, Thien Nguyen, Phuc Thai, Bui, Thuy Thu, Tra, Hien Nhat, Nguyen, Tung Thanh, Son Phan, Nam Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057481/
https://www.ncbi.nlm.nih.gov/pubmed/35520859
http://dx.doi.org/10.1039/d0ra03047c
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author Pham, Phuc Hoang
Thien Nguyen, Phuc Thai
Bui, Thuy Thu
Tra, Hien Nhat
Nguyen, Tung Thanh
Son Phan, Nam Thanh
author_facet Pham, Phuc Hoang
Thien Nguyen, Phuc Thai
Bui, Thuy Thu
Tra, Hien Nhat
Nguyen, Tung Thanh
Son Phan, Nam Thanh
author_sort Pham, Phuc Hoang
collection PubMed
description Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, trifluoromethyl, cyano, methylthio, and heteroaryl groups were well tolerated.
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spelling pubmed-90574812022-05-04 Homo-condensation of acetophenones toward imidazothiones Pham, Phuc Hoang Thien Nguyen, Phuc Thai Bui, Thuy Thu Tra, Hien Nhat Nguyen, Tung Thanh Son Phan, Nam Thanh RSC Adv Chemistry Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, trifluoromethyl, cyano, methylthio, and heteroaryl groups were well tolerated. The Royal Society of Chemistry 2020-11-04 /pmc/articles/PMC9057481/ /pubmed/35520859 http://dx.doi.org/10.1039/d0ra03047c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pham, Phuc Hoang
Thien Nguyen, Phuc Thai
Bui, Thuy Thu
Tra, Hien Nhat
Nguyen, Tung Thanh
Son Phan, Nam Thanh
Homo-condensation of acetophenones toward imidazothiones
title Homo-condensation of acetophenones toward imidazothiones
title_full Homo-condensation of acetophenones toward imidazothiones
title_fullStr Homo-condensation of acetophenones toward imidazothiones
title_full_unstemmed Homo-condensation of acetophenones toward imidazothiones
title_short Homo-condensation of acetophenones toward imidazothiones
title_sort homo-condensation of acetophenones toward imidazothiones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057481/
https://www.ncbi.nlm.nih.gov/pubmed/35520859
http://dx.doi.org/10.1039/d0ra03047c
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