Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa

Pycnidiophorones A–D (1–4), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0(2,7)]dodecane core, and six known depsidones (5–10) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa. Their chemical stru...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Chen, Liu, Gaoran, Liu, Xingzhong, Zhang, Lan, Li, Lin, Liu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057502/
https://www.ncbi.nlm.nih.gov/pubmed/35520825
http://dx.doi.org/10.1039/d0ra08072a
_version_ 1784697911207002112
author Zhao, Chen
Liu, Gaoran
Liu, Xingzhong
Zhang, Lan
Li, Lin
Liu, Ling
author_facet Zhao, Chen
Liu, Gaoran
Liu, Xingzhong
Zhang, Lan
Li, Lin
Liu, Ling
author_sort Zhao, Chen
collection PubMed
description Pycnidiophorones A–D (1–4), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0(2,7)]dodecane core, and six known depsidones (5–10) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa. Their chemical structures were unambiguously determined using NMR spectroscopic data. The absolute configurations of 1 and 3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1–10 showed moderate cytotoxicity against a panel of five human tumor cell lines.
format Online
Article
Text
id pubmed-9057502
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90575022022-05-04 Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa Zhao, Chen Liu, Gaoran Liu, Xingzhong Zhang, Lan Li, Lin Liu, Ling RSC Adv Chemistry Pycnidiophorones A–D (1–4), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0(2,7)]dodecane core, and six known depsidones (5–10) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa. Their chemical structures were unambiguously determined using NMR spectroscopic data. The absolute configurations of 1 and 3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1–10 showed moderate cytotoxicity against a panel of five human tumor cell lines. The Royal Society of Chemistry 2020-11-05 /pmc/articles/PMC9057502/ /pubmed/35520825 http://dx.doi.org/10.1039/d0ra08072a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhao, Chen
Liu, Gaoran
Liu, Xingzhong
Zhang, Lan
Li, Lin
Liu, Ling
Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title_full Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title_fullStr Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title_full_unstemmed Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title_short Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa
title_sort pycnidiophorones a–d, four new cytochalasans from the wetland derived fungus pycnidiophora dispersa
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057502/
https://www.ncbi.nlm.nih.gov/pubmed/35520825
http://dx.doi.org/10.1039/d0ra08072a
work_keys_str_mv AT zhaochen pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa
AT liugaoran pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa
AT liuxingzhong pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa
AT zhanglan pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa
AT lilin pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa
AT liuling pycnidiophoronesadfournewcytochalasansfromthewetlandderivedfunguspycnidiophoradispersa

Ejemplares similares