Mitochondria-derived peptides in aging and healthspan

The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to be studied, but one element has been unexplored: microproteins. Small open reading frames in circular mitochondria DNA can encode multiple microproteins, called mitochondria-derived peptides (MDPs). Currently,...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Brendan, Kim, Su-Jeong, Kumagai, Hiroshi, Yen, Kelvin, Cohen, Pinchas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Review Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057581/
https://www.ncbi.nlm.nih.gov/pubmed/35499074
http://dx.doi.org/10.1172/JCI158449
_version_ 1784697930225025024
author Miller, Brendan
Kim, Su-Jeong
Kumagai, Hiroshi
Yen, Kelvin
Cohen, Pinchas
author_facet Miller, Brendan
Kim, Su-Jeong
Kumagai, Hiroshi
Yen, Kelvin
Cohen, Pinchas
author_sort Miller, Brendan
collection PubMed
description The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to be studied, but one element has been unexplored: microproteins. Small open reading frames in circular mitochondria DNA can encode multiple microproteins, called mitochondria-derived peptides (MDPs). Currently, eight MDPs have been published: humanin, MOTS-c, and SHLPs 1–6. This Review describes recent advances in microprotein discovery with a focus on MDPs. It discusses what is currently known about MDPs in aging and how this new understanding could add to the way we understand age-related diseases including type 2 diabetes, cancer, and neurodegenerative diseases at the genomic, proteomic, and drug-development levels.
format Online
Article
Text
id pubmed-9057581
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Clinical Investigation
record_format MEDLINE/PubMed
spelling pubmed-90575812022-05-04 Mitochondria-derived peptides in aging and healthspan Miller, Brendan Kim, Su-Jeong Kumagai, Hiroshi Yen, Kelvin Cohen, Pinchas J Clin Invest Review Series The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to be studied, but one element has been unexplored: microproteins. Small open reading frames in circular mitochondria DNA can encode multiple microproteins, called mitochondria-derived peptides (MDPs). Currently, eight MDPs have been published: humanin, MOTS-c, and SHLPs 1–6. This Review describes recent advances in microprotein discovery with a focus on MDPs. It discusses what is currently known about MDPs in aging and how this new understanding could add to the way we understand age-related diseases including type 2 diabetes, cancer, and neurodegenerative diseases at the genomic, proteomic, and drug-development levels. American Society for Clinical Investigation 2022-05-02 2022-05-02 /pmc/articles/PMC9057581/ /pubmed/35499074 http://dx.doi.org/10.1172/JCI158449 Text en © 2022 Miller et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Series
Miller, Brendan
Kim, Su-Jeong
Kumagai, Hiroshi
Yen, Kelvin
Cohen, Pinchas
Mitochondria-derived peptides in aging and healthspan
title Mitochondria-derived peptides in aging and healthspan
title_full Mitochondria-derived peptides in aging and healthspan
title_fullStr Mitochondria-derived peptides in aging and healthspan
title_full_unstemmed Mitochondria-derived peptides in aging and healthspan
title_short Mitochondria-derived peptides in aging and healthspan
title_sort mitochondria-derived peptides in aging and healthspan
topic Review Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057581/
https://www.ncbi.nlm.nih.gov/pubmed/35499074
http://dx.doi.org/10.1172/JCI158449
work_keys_str_mv AT millerbrendan mitochondriaderivedpeptidesinagingandhealthspan
AT kimsujeong mitochondriaderivedpeptidesinagingandhealthspan
AT kumagaihiroshi mitochondriaderivedpeptidesinagingandhealthspan
AT yenkelvin mitochondriaderivedpeptidesinagingandhealthspan
AT cohenpinchas mitochondriaderivedpeptidesinagingandhealthspan

Ejemplares similares