Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8(+) T cells in pancreatic cancer

We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality. Antigenicity promotes accumulation of type 1 dendritic cells (cDC1), which is driven by Xcr1 signaling, and...

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Detalles Bibliográficos
Autores principales: Burrack, Adam L., Schmiechen, Zoe C., Patterson, Michael T., Miller, Ebony A., Spartz, Ellen J., Rollins, Meagan R., Raynor, Jackson F., Mitchell, Jason S., Kaisho, Tsuneyasu, Fife, Brian T., Stromnes, Ingunn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057584/
https://www.ncbi.nlm.nih.gov/pubmed/35393950
http://dx.doi.org/10.1172/jci.insight.151593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057584/
https://www.ncbi.nlm.nih.gov/pubmed/35393950
http://dx.doi.org/10.1172/jci.insight.151593

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