Tim-3 mediates T cell trogocytosis to limit antitumor immunity

T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanoma. Here, we show that human programmed cell death...

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Detalles Bibliográficos
Autores principales: Pagliano, Ornella, Morrison, Robert M., Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R., DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C., Sander, Cindy, Kirkwood, John M., Bosenberg, Marcus, Anderson, Ana C., Kuchroo, Vijay K., Kane, Lawrence P., Korman, Alan J., Rajpal, Arvind, West, Sean M., Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057587/
https://www.ncbi.nlm.nih.gov/pubmed/35316223
http://dx.doi.org/10.1172/JCI152864

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