Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy

The glomerular filtration barrier (GFB) produces primary urine and is composed of a fenestrated endothelium, a glomerular basement membrane (GBM), podocytes, and a slit diaphragm. Impairment of the GFB leads to albuminuria and microhematuria. The GBM is generated via secreted proteins from both endo...

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Detalles Bibliográficos
Autores principales: Aypek, Hande, Krisp, Christoph, Lu, Shun, Liu, Shuya, Kylies, Dominik, Kretz, Oliver, Wu, Guochao, Moritz, Manuela, Amann, Kerstin, Benz, Kerstin, Tong, Ping, Hu, Zheng-mao, Alsulaiman, Sulaiman M., Khan, Arif O., Grohmann, Maik, Wagner, Timo, Müller-Deile, Janina, Schlüter, Hartmut, Puelles, Victor G., Bergmann, Carsten, Huber, Tobias B., Grahammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057608/
https://www.ncbi.nlm.nih.gov/pubmed/35499085
http://dx.doi.org/10.1172/JCI147253

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