Blockade of the CXCR3/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction

Immunoproteasomes regulate the degradation of ubiquitin-coupled proteins and generate peptides that are preferentially presented by MHC class I. Mutations in immunoproteasome subunits lead to immunoproteasome dysfunction, which causes proteasome-associated autoinflammatory syndromes (PRAAS) characte...

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Detalles Bibliográficos
Autores principales: Sasaki, Yuki, Arimochi, Hideki, Otsuka, Kunihiro, Kondo, Hiroyuki, Tsukumo, Shin-ichi, Yasutomo, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057626/
https://www.ncbi.nlm.nih.gov/pubmed/35393946
http://dx.doi.org/10.1172/jci.insight.152681

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