Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis. However, the link between BAT inflammation and systematic metabo...

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Detalles Bibliográficos
Autores principales: Huang, Yanrui, Zhou, Jenny H., Zhang, Haifeng, Canfran-Duque, Alberto, Singh, Abhishek K., Perry, Rachel J., Shulman, Gerald I., Fernandez-Hernando, Carlos, Min, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057632/
https://www.ncbi.nlm.nih.gov/pubmed/35202005
http://dx.doi.org/10.1172/JCI148852

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