Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature

Cabozantinib is a novel multitargeted receptor tyrosine kinase inhibitor commonly used to treat advanced renal cell carcinoma. Cardiotoxicity is not a previously well-described adverse effect of cabozantinib. We present a rare case of a 74-year-old male with a history of renal cell carcinoma who und...

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Detalles Bibliográficos
Autores principales: Buttar, Chandan, Lakhdar, Sofia, Nassar, Mahmoud, Landry, Ian, Munira, Most
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057634/
https://www.ncbi.nlm.nih.gov/pubmed/35509750
http://dx.doi.org/10.7759/cureus.23740
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author Buttar, Chandan
Lakhdar, Sofia
Nassar, Mahmoud
Landry, Ian
Munira, Most
author_facet Buttar, Chandan
Lakhdar, Sofia
Nassar, Mahmoud
Landry, Ian
Munira, Most
author_sort Buttar, Chandan
collection PubMed
description Cabozantinib is a novel multitargeted receptor tyrosine kinase inhibitor commonly used to treat advanced renal cell carcinoma. Cardiotoxicity is not a previously well-described adverse effect of cabozantinib. We present a rare case of a 74-year-old male with a history of renal cell carcinoma who underwent partial nephrectomy. The patient had been recently started on cabozantinib for advanced metastatic renal cell carcinoma. He developed acute onset of heart failure and subclinical hypothyroidism within nine months of treatment. Our case report postulates a causal relationship between cabozantinib and the development of non-ischemic cardiomyopathy.
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spelling pubmed-90576342022-05-03 Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature Buttar, Chandan Lakhdar, Sofia Nassar, Mahmoud Landry, Ian Munira, Most Cureus Cardiology Cabozantinib is a novel multitargeted receptor tyrosine kinase inhibitor commonly used to treat advanced renal cell carcinoma. Cardiotoxicity is not a previously well-described adverse effect of cabozantinib. We present a rare case of a 74-year-old male with a history of renal cell carcinoma who underwent partial nephrectomy. The patient had been recently started on cabozantinib for advanced metastatic renal cell carcinoma. He developed acute onset of heart failure and subclinical hypothyroidism within nine months of treatment. Our case report postulates a causal relationship between cabozantinib and the development of non-ischemic cardiomyopathy. Cureus 2022-04-01 /pmc/articles/PMC9057634/ /pubmed/35509750 http://dx.doi.org/10.7759/cureus.23740 Text en Copyright © 2022, Buttar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Buttar, Chandan
Lakhdar, Sofia
Nassar, Mahmoud
Landry, Ian
Munira, Most
Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title_full Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title_fullStr Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title_full_unstemmed Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title_short Cabozantinib-Induced Severe Cardiac Dysfunction: A Case Report and a Systematic Review of the Literature
title_sort cabozantinib-induced severe cardiac dysfunction: a case report and a systematic review of the literature
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057634/
https://www.ncbi.nlm.nih.gov/pubmed/35509750
http://dx.doi.org/10.7759/cureus.23740
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