Diagnostic workup of inherited platelet disorders

Inherited platelet disorders (IPDs) can cause mucocutaneous bleeding due to impaired primary hemostatic function of platelets, thrombocytopenia, or both. Recent advances in molecular technology can help identify many genes related to platelet biology, control the overall steps of megakaryopoiesis, a...

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Detalles Bibliográficos
Autor principal: Kim, Bohyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057669/
https://www.ncbi.nlm.nih.gov/pubmed/35483920
http://dx.doi.org/10.5045/br.2022.2021223
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author Kim, Bohyun
author_facet Kim, Bohyun
author_sort Kim, Bohyun
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description Inherited platelet disorders (IPDs) can cause mucocutaneous bleeding due to impaired primary hemostatic function of platelets, thrombocytopenia, or both. Recent advances in molecular technology can help identify many genes related to platelet biology, control the overall steps of megakaryopoiesis, and cause IPD. In this article, currently available laboratory tools for diagnosing IPDs with the characteristic laboratory features of each IPD are reviewed, and a general diagnostic approach for the evaluation of IPD patients is presented.
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spelling pubmed-90576692022-05-10 Diagnostic workup of inherited platelet disorders Kim, Bohyun Blood Res Review Article Inherited platelet disorders (IPDs) can cause mucocutaneous bleeding due to impaired primary hemostatic function of platelets, thrombocytopenia, or both. Recent advances in molecular technology can help identify many genes related to platelet biology, control the overall steps of megakaryopoiesis, and cause IPD. In this article, currently available laboratory tools for diagnosing IPDs with the characteristic laboratory features of each IPD are reviewed, and a general diagnostic approach for the evaluation of IPD patients is presented. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2022-04-30 2022-04-30 /pmc/articles/PMC9057669/ /pubmed/35483920 http://dx.doi.org/10.5045/br.2022.2021223 Text en © 2022 Korean Society of Hematology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Bohyun
Diagnostic workup of inherited platelet disorders
title Diagnostic workup of inherited platelet disorders
title_full Diagnostic workup of inherited platelet disorders
title_fullStr Diagnostic workup of inherited platelet disorders
title_full_unstemmed Diagnostic workup of inherited platelet disorders
title_short Diagnostic workup of inherited platelet disorders
title_sort diagnostic workup of inherited platelet disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057669/
https://www.ncbi.nlm.nih.gov/pubmed/35483920
http://dx.doi.org/10.5045/br.2022.2021223
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