Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compou...

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Autores principales: Uppala, Sivaranjan, Gamliel, Ayelet, Sapir, Gal, Sosna, Jacob, Gomori, J. Moshe, Katz-Brull, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057779/
https://www.ncbi.nlm.nih.gov/pubmed/35519178
http://dx.doi.org/10.1039/d0ra08022e
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author Uppala, Sivaranjan
Gamliel, Ayelet
Sapir, Gal
Sosna, Jacob
Gomori, J. Moshe
Katz-Brull, Rachel
author_facet Uppala, Sivaranjan
Gamliel, Ayelet
Sapir, Gal
Sosna, Jacob
Gomori, J. Moshe
Katz-Brull, Rachel
author_sort Uppala, Sivaranjan
collection PubMed
description A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was ca. 1.6.
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spelling pubmed-90577792022-05-04 Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR Uppala, Sivaranjan Gamliel, Ayelet Sapir, Gal Sosna, Jacob Gomori, J. Moshe Katz-Brull, Rachel RSC Adv Chemistry A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was ca. 1.6. The Royal Society of Chemistry 2020-11-11 /pmc/articles/PMC9057779/ /pubmed/35519178 http://dx.doi.org/10.1039/d0ra08022e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Uppala, Sivaranjan
Gamliel, Ayelet
Sapir, Gal
Sosna, Jacob
Gomori, J. Moshe
Katz-Brull, Rachel
Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title_full Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title_fullStr Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title_full_unstemmed Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title_short Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR
title_sort observation of glucose-6-phosphate anomeric exchange in real-time using ddnp hyperpolarised nmr
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057779/
https://www.ncbi.nlm.nih.gov/pubmed/35519178
http://dx.doi.org/10.1039/d0ra08022e
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