The emerging roles of retromer and sorting nexins in the life cycle of viruses

Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of...

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Detalles Bibliográficos
Autores principales: Lu, Yue, He, Ping, Zhang, Yuxuan, Ren, Yongwen, Zhang, Leiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057928/
https://www.ncbi.nlm.nih.gov/pubmed/35513271
http://dx.doi.org/10.1016/j.virs.2022.04.014
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author Lu, Yue
He, Ping
Zhang, Yuxuan
Ren, Yongwen
Zhang, Leiliang
author_facet Lu, Yue
He, Ping
Zhang, Yuxuan
Ren, Yongwen
Zhang, Leiliang
author_sort Lu, Yue
collection PubMed
description Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.
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spelling pubmed-90579282022-05-02 The emerging roles of retromer and sorting nexins in the life cycle of viruses Lu, Yue He, Ping Zhang, Yuxuan Ren, Yongwen Zhang, Leiliang Virol Sin Review Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-05-02 /pmc/articles/PMC9057928/ /pubmed/35513271 http://dx.doi.org/10.1016/j.virs.2022.04.014 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Lu, Yue
He, Ping
Zhang, Yuxuan
Ren, Yongwen
Zhang, Leiliang
The emerging roles of retromer and sorting nexins in the life cycle of viruses
title The emerging roles of retromer and sorting nexins in the life cycle of viruses
title_full The emerging roles of retromer and sorting nexins in the life cycle of viruses
title_fullStr The emerging roles of retromer and sorting nexins in the life cycle of viruses
title_full_unstemmed The emerging roles of retromer and sorting nexins in the life cycle of viruses
title_short The emerging roles of retromer and sorting nexins in the life cycle of viruses
title_sort emerging roles of retromer and sorting nexins in the life cycle of viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057928/
https://www.ncbi.nlm.nih.gov/pubmed/35513271
http://dx.doi.org/10.1016/j.virs.2022.04.014
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