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Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis
Osteoarthritis (OA) is the most common joint disease in elderly individuals and seriously affects quality of life. OA has often been thought to be caused by body weight load, but studies have increasingly shown that OA is an inflammation-mediated metabolic disease. The current existing evidence sugg...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058006/ https://www.ncbi.nlm.nih.gov/pubmed/35510046 http://dx.doi.org/10.2147/DMSO.S359330 |
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author | Jiang, Hai Pu, Yu Li, Zeng-Hui Liu, Wei Deng, Yan Liang, Rui Zhang, Xiao-Ming Zuo, Hou-Dong |
author_facet | Jiang, Hai Pu, Yu Li, Zeng-Hui Liu, Wei Deng, Yan Liang, Rui Zhang, Xiao-Ming Zuo, Hou-Dong |
author_sort | Jiang, Hai |
collection | PubMed |
description | Osteoarthritis (OA) is the most common joint disease in elderly individuals and seriously affects quality of life. OA has often been thought to be caused by body weight load, but studies have increasingly shown that OA is an inflammation-mediated metabolic disease. The current existing evidence suggests that OA is associated with obesity-related chronic inflammation as well as abnormal lipid metabolism in obesity, such as fatty acids (FA) and triglycerides. Adiponectin, a cytokine secreted by adipose tissue, can affect the progression of OA by regulating obesity-related inflammatory factors. However, the specific molecular mechanism has not been fully elucidated. According to previous research, adiponectin can promote the metabolism of FA and triglycerides, which indicates that it is a potential protective factor for OA through many mechanisms. This article aims to review the mechanisms of chronic inflammation, FA and triglycerides in OA, as well as the potential mechanisms of adiponectin in regulating chronic inflammation and promoting FA and triglyceride metabolism. Therefore, adiponectin may have a protective effect on obesity-related OA, which could provide new insight into adiponectin and the related mechanisms in OA. |
format | Online Article Text |
id | pubmed-9058006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-90580062022-05-03 Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis Jiang, Hai Pu, Yu Li, Zeng-Hui Liu, Wei Deng, Yan Liang, Rui Zhang, Xiao-Ming Zuo, Hou-Dong Diabetes Metab Syndr Obes Review Osteoarthritis (OA) is the most common joint disease in elderly individuals and seriously affects quality of life. OA has often been thought to be caused by body weight load, but studies have increasingly shown that OA is an inflammation-mediated metabolic disease. The current existing evidence suggests that OA is associated with obesity-related chronic inflammation as well as abnormal lipid metabolism in obesity, such as fatty acids (FA) and triglycerides. Adiponectin, a cytokine secreted by adipose tissue, can affect the progression of OA by regulating obesity-related inflammatory factors. However, the specific molecular mechanism has not been fully elucidated. According to previous research, adiponectin can promote the metabolism of FA and triglycerides, which indicates that it is a potential protective factor for OA through many mechanisms. This article aims to review the mechanisms of chronic inflammation, FA and triglycerides in OA, as well as the potential mechanisms of adiponectin in regulating chronic inflammation and promoting FA and triglyceride metabolism. Therefore, adiponectin may have a protective effect on obesity-related OA, which could provide new insight into adiponectin and the related mechanisms in OA. Dove 2022-04-27 /pmc/articles/PMC9058006/ /pubmed/35510046 http://dx.doi.org/10.2147/DMSO.S359330 Text en © 2022 Jiang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Jiang, Hai Pu, Yu Li, Zeng-Hui Liu, Wei Deng, Yan Liang, Rui Zhang, Xiao-Ming Zuo, Hou-Dong Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title | Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title_full | Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title_fullStr | Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title_full_unstemmed | Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title_short | Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis |
title_sort | adiponectin, may be a potential protective factor for obesity-related osteoarthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058006/ https://www.ncbi.nlm.nih.gov/pubmed/35510046 http://dx.doi.org/10.2147/DMSO.S359330 |
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