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The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study

In alcohol withdrawal syndrome (AWS), pathophysiological mechanisms cover acid-base disturbances that affect the clinical picture of this state. An earlier study found that oxygen therapy methods in combination with pharmacotherapy improved the cognitive state in persons suffering from AWS. As impai...

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Autores principales: Kapytau, Dzmitry, Kapytau, Andrei, Khrushch, Inessa, Kudin, Ludmila, Waszkiewicz, Napoleon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058062/
https://www.ncbi.nlm.nih.gov/pubmed/35509880
http://dx.doi.org/10.3389/fpsyt.2022.819154
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author Kapytau, Dzmitry
Kapytau, Andrei
Khrushch, Inessa
Kudin, Ludmila
Waszkiewicz, Napoleon
author_facet Kapytau, Dzmitry
Kapytau, Andrei
Khrushch, Inessa
Kudin, Ludmila
Waszkiewicz, Napoleon
author_sort Kapytau, Dzmitry
collection PubMed
description In alcohol withdrawal syndrome (AWS), pathophysiological mechanisms cover acid-base disturbances that affect the clinical picture of this state. An earlier study found that oxygen therapy methods in combination with pharmacotherapy improved the cognitive state in persons suffering from AWS. As impairments in the acid-base state influence the general health, timely and effective correction of these acid-base disturbances could result in a potential improvement in the treatment of the alcohol withdrawal symptoms. Therefore, the aim of this study was to evaluate the effectiveness of non-compressed oxygen therapy (NOT) and hyperbaric oxygenation (HBO) in combination with standard drug therapy (SDT), based on the dynamics of the acid-base state (ABS) in blood during AWS. HBO is the use of oxygen under pressure, whereas NOT uses oxygen without pressure. A comparative assessment of the acid-base state biomarkers was made in 160 patients with a moderate alcohol withdrawal state (3 groups), namely, in patients who underwent SDT only (control group/CG; n = 42) and two comparison groups who underwent SDT in combination with NOT (SG1 group; n = 56) and HBO (SG2 group; n = 62). The use of both oxygen therapy methods (i.e., NOT and HBO) in combination with SDT corrected the ABS in a shorter time and more effectively, which was due to the better restoration of the carbonate buffer system. Although we did not find proof that novel oxygen-related therapeutic procedures such as NOT and HBO in combination with SDT improved the alcohol withdrawal symptoms, it helped with the faster restoration of the acid-base state.
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spelling pubmed-90580622022-05-03 The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study Kapytau, Dzmitry Kapytau, Andrei Khrushch, Inessa Kudin, Ludmila Waszkiewicz, Napoleon Front Psychiatry Psychiatry In alcohol withdrawal syndrome (AWS), pathophysiological mechanisms cover acid-base disturbances that affect the clinical picture of this state. An earlier study found that oxygen therapy methods in combination with pharmacotherapy improved the cognitive state in persons suffering from AWS. As impairments in the acid-base state influence the general health, timely and effective correction of these acid-base disturbances could result in a potential improvement in the treatment of the alcohol withdrawal symptoms. Therefore, the aim of this study was to evaluate the effectiveness of non-compressed oxygen therapy (NOT) and hyperbaric oxygenation (HBO) in combination with standard drug therapy (SDT), based on the dynamics of the acid-base state (ABS) in blood during AWS. HBO is the use of oxygen under pressure, whereas NOT uses oxygen without pressure. A comparative assessment of the acid-base state biomarkers was made in 160 patients with a moderate alcohol withdrawal state (3 groups), namely, in patients who underwent SDT only (control group/CG; n = 42) and two comparison groups who underwent SDT in combination with NOT (SG1 group; n = 56) and HBO (SG2 group; n = 62). The use of both oxygen therapy methods (i.e., NOT and HBO) in combination with SDT corrected the ABS in a shorter time and more effectively, which was due to the better restoration of the carbonate buffer system. Although we did not find proof that novel oxygen-related therapeutic procedures such as NOT and HBO in combination with SDT improved the alcohol withdrawal symptoms, it helped with the faster restoration of the acid-base state. Frontiers Media S.A. 2022-04-18 /pmc/articles/PMC9058062/ /pubmed/35509880 http://dx.doi.org/10.3389/fpsyt.2022.819154 Text en Copyright © 2022 Kapytau, Kapytau, Khrushch, Kudin and Waszkiewicz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Kapytau, Dzmitry
Kapytau, Andrei
Khrushch, Inessa
Kudin, Ludmila
Waszkiewicz, Napoleon
The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title_full The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title_fullStr The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title_full_unstemmed The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title_short The Effect of the Non-compressed Oxygen Therapy and Hyperbaric Oxygenation in Combination With Standardized Drug Therapy on the Blood Acid-Base State Biomarkers in Alcohol Withdrawal Syndrome, an Experimental Study
title_sort effect of the non-compressed oxygen therapy and hyperbaric oxygenation in combination with standardized drug therapy on the blood acid-base state biomarkers in alcohol withdrawal syndrome, an experimental study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058062/
https://www.ncbi.nlm.nih.gov/pubmed/35509880
http://dx.doi.org/10.3389/fpsyt.2022.819154
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