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Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals
OBJECTIVE: Using a newly released National Health and Nutrition Examination Survey (NHANES) data of serum Klotho, this study aimed to explore the relationship between Klotho and specific cardiovascular diseases (CVD), as well as the mediation effect of renal function, among middle-aged and older ind...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058082/ https://www.ncbi.nlm.nih.gov/pubmed/35509269 http://dx.doi.org/10.3389/fcvm.2022.802287 |
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author | Zhu, Xu Lu, Xinyi Yin, Ting Zhu, Qingqing Shi, Shi Cheang, Iokfai Yue, Xin Tang, Yuan Liao, Shengen Zhou, Yanli Zhang, Haifeng Li, Xinli Yao, Wenming |
author_facet | Zhu, Xu Lu, Xinyi Yin, Ting Zhu, Qingqing Shi, Shi Cheang, Iokfai Yue, Xin Tang, Yuan Liao, Shengen Zhou, Yanli Zhang, Haifeng Li, Xinli Yao, Wenming |
author_sort | Zhu, Xu |
collection | PubMed |
description | OBJECTIVE: Using a newly released National Health and Nutrition Examination Survey (NHANES) data of serum Klotho, this study aimed to explore the relationship between Klotho and specific cardiovascular diseases (CVD), as well as the mediation effect of renal function, among middle-aged and older individuals within the general population. METHODS: This nationally representative cross-sectional study analyzed data from the 2007–2016 NHANES. A total of 13,765 participants, who aged 40 years or older, from the general population were examined. Klotho were divided into four groups based on median and interquartile range. The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis. RESULTS: In comparison to the lowest quartile, Klotho in the highest quartile was independently associated with the prevalence of CHF (OR 0.59; 95% CI 0.46–0.77, p for trend = 0.001), but not with other individual CVDs. Klotho had a significant direct effect on the prevalence of CHF (all p < 0.001), while eGFR, BUN, UA, and UACR partly mediated the indirect effect of Klotho on the prevalence of CHF (all p < 0.05), explaining 19.51, 6.98, 13.93, and 0.71% of the association between Klotho and CHF, respectively. Additionally, restricted cubic spline regression demonstrated a linear association and negative correlation between Klotho level and CHF. CONCLUSION: These findings suggest that Klotho is closely linked to CHF and renal function may be a key mediator of this association. |
format | Online Article Text |
id | pubmed-9058082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90580822022-05-03 Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals Zhu, Xu Lu, Xinyi Yin, Ting Zhu, Qingqing Shi, Shi Cheang, Iokfai Yue, Xin Tang, Yuan Liao, Shengen Zhou, Yanli Zhang, Haifeng Li, Xinli Yao, Wenming Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: Using a newly released National Health and Nutrition Examination Survey (NHANES) data of serum Klotho, this study aimed to explore the relationship between Klotho and specific cardiovascular diseases (CVD), as well as the mediation effect of renal function, among middle-aged and older individuals within the general population. METHODS: This nationally representative cross-sectional study analyzed data from the 2007–2016 NHANES. A total of 13,765 participants, who aged 40 years or older, from the general population were examined. Klotho were divided into four groups based on median and interquartile range. The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis. RESULTS: In comparison to the lowest quartile, Klotho in the highest quartile was independently associated with the prevalence of CHF (OR 0.59; 95% CI 0.46–0.77, p for trend = 0.001), but not with other individual CVDs. Klotho had a significant direct effect on the prevalence of CHF (all p < 0.001), while eGFR, BUN, UA, and UACR partly mediated the indirect effect of Klotho on the prevalence of CHF (all p < 0.05), explaining 19.51, 6.98, 13.93, and 0.71% of the association between Klotho and CHF, respectively. Additionally, restricted cubic spline regression demonstrated a linear association and negative correlation between Klotho level and CHF. CONCLUSION: These findings suggest that Klotho is closely linked to CHF and renal function may be a key mediator of this association. Frontiers Media S.A. 2022-04-18 /pmc/articles/PMC9058082/ /pubmed/35509269 http://dx.doi.org/10.3389/fcvm.2022.802287 Text en Copyright © 2022 Zhu, Lu, Yin, Zhu, Shi, Cheang, Yue, Tang, Liao, Zhou, Zhang, Li and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Zhu, Xu Lu, Xinyi Yin, Ting Zhu, Qingqing Shi, Shi Cheang, Iokfai Yue, Xin Tang, Yuan Liao, Shengen Zhou, Yanli Zhang, Haifeng Li, Xinli Yao, Wenming Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title | Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title_full | Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title_fullStr | Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title_full_unstemmed | Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title_short | Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals |
title_sort | renal function mediates the association between klotho and congestive heart failure among middle-aged and older individuals |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058082/ https://www.ncbi.nlm.nih.gov/pubmed/35509269 http://dx.doi.org/10.3389/fcvm.2022.802287 |
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