1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are des...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Min-Qi, Li, Heng, Lin, Ying, Zhang, Ying, Tang, Jie, Zuo, Jian-Ping, Yu, Li-Fang, Tong, Xian-Kun, Tang, Wei, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058255/
https://www.ncbi.nlm.nih.gov/pubmed/35519683
http://dx.doi.org/10.1039/d0ra08442e
Descripción
Sumario:Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

Ejemplares similares