1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are des...

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Autores principales: Hu, Min-Qi, Li, Heng, Lin, Ying, Zhang, Ying, Tang, Jie, Zuo, Jian-Ping, Yu, Li-Fang, Tong, Xian-Kun, Tang, Wei, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058255/
https://www.ncbi.nlm.nih.gov/pubmed/35519683
http://dx.doi.org/10.1039/d0ra08442e
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author Hu, Min-Qi
Li, Heng
Lin, Ying
Zhang, Ying
Tang, Jie
Zuo, Jian-Ping
Yu, Li-Fang
Tong, Xian-Kun
Tang, Wei
Yang, Fan
author_facet Hu, Min-Qi
Li, Heng
Lin, Ying
Zhang, Ying
Tang, Jie
Zuo, Jian-Ping
Yu, Li-Fang
Tong, Xian-Kun
Tang, Wei
Yang, Fan
author_sort Hu, Min-Qi
collection PubMed
description Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
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spelling pubmed-90582552022-05-04 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors Hu, Min-Qi Li, Heng Lin, Ying Zhang, Ying Tang, Jie Zuo, Jian-Ping Yu, Li-Fang Tong, Xian-Kun Tang, Wei Yang, Fan RSC Adv Chemistry Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs. The Royal Society of Chemistry 2020-12-07 /pmc/articles/PMC9058255/ /pubmed/35519683 http://dx.doi.org/10.1039/d0ra08442e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hu, Min-Qi
Li, Heng
Lin, Ying
Zhang, Ying
Tang, Jie
Zuo, Jian-Ping
Yu, Li-Fang
Tong, Xian-Kun
Tang, Wei
Yang, Fan
1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title_full 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title_fullStr 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title_full_unstemmed 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title_short 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
title_sort 1-phenyl-n-(benzothiazol-2-yl)methanimine derivatives as middle east respiratory syndrome coronavirus inhibitors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058255/
https://www.ncbi.nlm.nih.gov/pubmed/35519683
http://dx.doi.org/10.1039/d0ra08442e
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