Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues

Three lamellarin alkaloids type III (lamellarin R, lukianol A and lamellarin O) were synthesized using the Barton–Zard reaction as a key step to construct the central pyrrole core. Some of their corresponding 4-benzoyl and 5-phenyl substituted pyrrole analogues were also prepared via an initial thre...

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Detalles Bibliográficos
Autores principales: Satyanarayana, Iddum, Yang, Ding-Yah, Liou, Teau-Jiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058285/
https://www.ncbi.nlm.nih.gov/pubmed/35514893
http://dx.doi.org/10.1039/d0ra09249e
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author Satyanarayana, Iddum
Yang, Ding-Yah
Liou, Teau-Jiuan
author_facet Satyanarayana, Iddum
Yang, Ding-Yah
Liou, Teau-Jiuan
author_sort Satyanarayana, Iddum
collection PubMed
description Three lamellarin alkaloids type III (lamellarin R, lukianol A and lamellarin O) were synthesized using the Barton–Zard reaction as a key step to construct the central pyrrole core. Some of their corresponding 4-benzoyl and 5-phenyl substituted pyrrole analogues were also prepared via an initial three-component reaction of glycine methyl ester, benzaldehyde, and chalcone to generate the pyrrolidine scaffold, and followed by DDQ oxidation and N-alkylation.
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spelling pubmed-90582852022-05-04 Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues Satyanarayana, Iddum Yang, Ding-Yah Liou, Teau-Jiuan RSC Adv Chemistry Three lamellarin alkaloids type III (lamellarin R, lukianol A and lamellarin O) were synthesized using the Barton–Zard reaction as a key step to construct the central pyrrole core. Some of their corresponding 4-benzoyl and 5-phenyl substituted pyrrole analogues were also prepared via an initial three-component reaction of glycine methyl ester, benzaldehyde, and chalcone to generate the pyrrolidine scaffold, and followed by DDQ oxidation and N-alkylation. The Royal Society of Chemistry 2020-11-27 /pmc/articles/PMC9058285/ /pubmed/35514893 http://dx.doi.org/10.1039/d0ra09249e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Satyanarayana, Iddum
Yang, Ding-Yah
Liou, Teau-Jiuan
Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title_full Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title_fullStr Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title_full_unstemmed Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title_short Synthesis of lamellarin R, lukianol A, lamellarin O and their analogues
title_sort synthesis of lamellarin r, lukianol a, lamellarin o and their analogues
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058285/
https://www.ncbi.nlm.nih.gov/pubmed/35514893
http://dx.doi.org/10.1039/d0ra09249e
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