Synthesis of primary N-arylthioglyoxamides from anilines, elemental sulfur and primary C–H bonds in acetophenones

A simple method for coupling of anilines, acetophenones, and elemental sulfur to afford N-arylthioglyoxamides has been developed. Reactions proceeded in the presence of Na(2)SO(3) and DMSO, thus eliminating the need for transition metals and external oxidants. Functionalities such as halogen, ester,...

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Detalles Bibliográficos
Autores principales: Tran, Khoa M., Nguyen, Nguyen H. K., Bui, Thuy T., To, Tuong A., Phan, Nam T. S., Le, Ha V., Nguyen, Tung T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058611/
https://www.ncbi.nlm.nih.gov/pubmed/35516277
http://dx.doi.org/10.1039/d0ra08740h
Descripción
Sumario:A simple method for coupling of anilines, acetophenones, and elemental sulfur to afford N-arylthioglyoxamides has been developed. Reactions proceeded in the presence of Na(2)SO(3) and DMSO, thus eliminating the need for transition metals and external oxidants. Functionalities such as halogen, ester, methylthio, and heterocycle groups were compatible with the conditions. Electron-poor acetophenones sometimes gave isosteric glyoxamides.

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