Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations

BACKGROUND: The number of randomized trials of agents targeting oncogene-addicted tumors has surged in the past 10 years. Using a meta-analysis, we explored whether improvements in objective response rate (ORR) in comparative trials using targeted agents could serve as a potential surrogate endpoint...

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Detalles Bibliográficos
Autores principales: Solomon, B.J., Loong, H.H., Summers, Y., Thomas, Z.M., French, P., Lin, B.K., Sashegyi, A., Wolf, J., Yang, J.C.-H., Drilon, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058889/
https://www.ncbi.nlm.nih.gov/pubmed/35183043
http://dx.doi.org/10.1016/j.esmoop.2022.100398

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