Prognostic impact of perineural invasion in oral cancer: a systematic review

INTRODUCTION: Numerous studies have evaluated the prognostic significance of perineural invasion (PNI) in oral cancer; however, the results are inconclusive. PURPOSE: To identify the prognostic value of PNI in oral cancer through a metanalysis. METHODS: A literature review was carried out, searching...

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Detalles Bibliográficos
Autores principales: Quintana, Debora Modelli Vianna Ocampo, Dedivitis, Rogerio Aparecido, Kowalski, Luiz Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058930/
https://www.ncbi.nlm.nih.gov/pubmed/35292785
http://dx.doi.org/10.14639/0392-100X-N1653
Descripción
Sumario:INTRODUCTION: Numerous studies have evaluated the prognostic significance of perineural invasion (PNI) in oral cancer; however, the results are inconclusive. PURPOSE: To identify the prognostic value of PNI in oral cancer through a metanalysis. METHODS: A literature review was carried out, searching the MedLine databases via Pubmed, Scielo, Lilacs, Cochrane and Websco. RESULTS: A total of 56 studies were included. The results indicate that PNI in oral cancer has an incidence of 28% (95% confidence interval (CI) 24-31%); 5-year survival with relative risk (RR) 0.67 (0.59-0.75); 5-year disease-free survival RR 0.71 (0.68-0.75); locoregional recurrence with RR 2.09 (1.86-2.35). CONCLUSIONS: PNI is a negative prognostic factor in oral cancer.

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