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Chronic rhinosinusitis with nasal polyps: how to identify eligible patients for biologics in clinical practice

OBJECTIVE: This study compared three severity measures for chronic rhinosinusitis with nasal polyps (CRSwNP). The outcome was to identify patients who are eligible for biological therapy. METHODS: 330 adult patients with CRSwNP were examined. Nasal polyp score (NPS), sinonasal outcome test (SNOT-22)...

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Detalles Bibliográficos
Autores principales: Gelardi, Matteo, Bocciolini, Corso, Notargiacomo, Mario, Schiavetti, Irene, Lingua, Cristiano, Pecoraro, Pietro, Iannuzzi, Lucia, Quaranta, Vitaliano Antonio, Giancaspro, Rossana, Ronca, Gianluca, Cassano, Michele, Ciprandi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058935/
https://www.ncbi.nlm.nih.gov/pubmed/35292789
http://dx.doi.org/10.14639/0392-100X-N1699
Descripción
Sumario:OBJECTIVE: This study compared three severity measures for chronic rhinosinusitis with nasal polyps (CRSwNP). The outcome was to identify patients who are eligible for biological therapy. METHODS: 330 adult patients with CRSwNP were examined. Nasal polyp score (NPS), sinonasal outcome test (SNOT-22) and clinical-cytological grading (CCG) were compared. Clinical history, past surgery and asthma control test were also considered. RESULTS: Only 45 (13.6%) patients had a contextual positivity to the three severity measures. The concordance among tests was slight/fair. Patients with severe disease (all tests positive) had more impaired parameters. The mixed cytotype (OR = 4.07), nasal obstruction (OR = 10.06), post-nasal drip (OR = 1.98), embarrassment (OR = 2.53) and difficulty falling asleep (OR = 1.92) were significantly associated with severe CRSwNP. CONCLUSIONS: To identify candidates for biological therapy, the contextual use of NPS, SNOT-22 and CCG is preferable. In this way, global assessment of CRSwNP, including morphology, inflammation, comorbidity, symptoms and quality of life is possible.