Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides

[Image: see text] Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2′)(7)), reported as melanocortin-3 receptor (MC3R) subtype-specific agonists in two separate publications, were found to lack significant MC3R agonist activity. The cell lines used at the Unive...

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Autores principales: Gimenez, Luis E., Noblin, Terry A., Williams, Savannah Y., Mullick Bagchi, Satarupa, Ji, Ren-Lei, Tao, Ya-Xiong, Jeppesen, Claus B., Conde-Frieboes, Kilian W., Sawyer, Tomi K., Grieco, Paolo, Cone, Roger D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059122/
https://www.ncbi.nlm.nih.gov/pubmed/35404053
http://dx.doi.org/10.1021/acs.jmedchem.1c01295

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