Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo

[Image: see text] Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to inhibit tumors that overexpress VDR. However, the current antagonists are arduous to synthesize and are only par...

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Detalles Bibliográficos
Autores principales: Khazan, Negar, Kim, Kyu Kwang, Hansen, Jeanne N., Singh, Niloy A., Moore, Taylor, Snyder, Cameron W. A., Pandita, Ravina, Strawderman, Myla, Fujihara, Michiko, Takamura, Yuta, Jian, Ye, Battaglia, Nicholas, Yano, Naohiro, Teramoto, Yuki, Arnold, Leggy A., Hopson, Russell, Kishor, Keshav, Nayak, Sneha, Ojha, Debasmita, Sharon, Ashoke, Ashton, John M., Wang, Jian, Milano, Michael T., Miyamoto, Hiroshi, Linehan, David C., Gerber, Scott A., Kawar, Nada, Singh, Ajay P., Tabdanov, Erdem D., Dokholyan, Nikolay V., Kakuta, Hiroki, Jurutka, Peter W., Schor, Nina F., Rowswell-Turner, Rachael B., Singh, Rakesh K., Moore, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059124/
https://www.ncbi.nlm.nih.gov/pubmed/35404047
http://dx.doi.org/10.1021/acs.jmedchem.1c01878

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