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Investigation of changes in protein stability and substrate affinity of 3CL-protease of SARS-CoV-2 caused by mutations

3CL(pro) of SARS-CoV-2 is one of the enzymes required for the replication process of the virus responsible for the COVID-19 pandemic. In this study, changes in protein stability and substrate affinity caused by mutations were investigated to stir the development of potent inhibitors. Sequence data o...

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Detalles Bibliográficos
Autor principal:	Akbulut, Ekrem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2022
Materias:	Genomics and Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059130/ https://www.ncbi.nlm.nih.gov/pubmed/35499274 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0404

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