A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics

Paclitaxel (PTX) is a major chemotherapeutic drug that is effective against a wide variety of cancers, particularly breast, ovarian and lung cancer. For a weakly basic chemotherapeutic drug such as PTX, the development of the acidic tumor microenvironment (Warburg effect) has a remarkable impact on...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Saswati, Khanam, Jasmina, Sarkar, Pradipta, Pal, Tapan Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059297/
https://www.ncbi.nlm.nih.gov/pubmed/35521568
http://dx.doi.org/10.1039/c8ra08924h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059297/
https://www.ncbi.nlm.nih.gov/pubmed/35521568
http://dx.doi.org/10.1039/c8ra08924h

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