Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group

The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm.

Detalles Bibliográficos
Autores principales: Goto, Yuya, Ueda, Masafumi, Sugikawa, Kouta, Yasuhara, Kazuma, Ikeda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059325/
https://www.ncbi.nlm.nih.gov/pubmed/35521599
http://dx.doi.org/10.1039/c8ra08584f
Descripción
Sumario:The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm.

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