Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation

Mutations in the C-terminal region of the CDC42 gene cause severe neonatal-onset autoinflammation. Effectiveness of IL-1β–blocking therapy indicates that the pathology involves abnormal inflammasome activation; however, the mechanism underlying autoinflammation remains to be elucidated. Using induce...

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Detalles Bibliográficos
Autores principales: Nishitani-Isa, Masahiko, Mukai, Kojiro, Honda, Yoshitaka, Nihira, Hiroshi, Tanaka, Takayuki, Shibata, Hirofumi, Kodama, Kumi, Hiejima, Eitaro, Izawa, Kazushi, Kawasaki, Yuri, Osawa, Mitsujiro, Katata, Yu, Onodera, Sachiko, Watanabe, Tatsuya, Uchida, Takashi, Kure, Shigeo, Takita, Junko, Ohara, Osamu, Saito, Megumu K., Nishikomori, Ryuta, Taguchi, Tomohiko, Sasahara, Yoji, Yasumi, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059393/
https://www.ncbi.nlm.nih.gov/pubmed/35482294
http://dx.doi.org/10.1084/jem.20211889

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