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Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties
Bone repairing materials play an essential role in the repair treatment of bone defects. The presence of calcium phosphate invertebrates is of significance for bone repairing processes. However, the mechanical properties and osteogenic activities of many current calcium phosphate materials are not i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059545/ https://www.ncbi.nlm.nih.gov/pubmed/35517622 http://dx.doi.org/10.1039/c8ra08453j |
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author | Xie, Lu Yang, Yuanyi Fu, Zhiqiang Li, Yunfei Shi, Jiacheng Ma, Daichuan Liu, Suilin Luo, Daibing |
author_facet | Xie, Lu Yang, Yuanyi Fu, Zhiqiang Li, Yunfei Shi, Jiacheng Ma, Daichuan Liu, Suilin Luo, Daibing |
author_sort | Xie, Lu |
collection | PubMed |
description | Bone repairing materials play an essential role in the repair treatment of bone defects. The presence of calcium phosphate invertebrates is of significance for bone repairing processes. However, the mechanical properties and osteogenic activities of many current calcium phosphate materials are not ideal, which limit their biological applications. Therefore, it is an effective alternative strategy to study the modification of calcium phosphate biomaterials to address these limitations. In this research, in order to enhance the biological performance of tricalcium phosphate (β-TCP), metal species (Fe and Zn) modified β-TCP materials through the co-precipitation method were successfully developed. The physical, chemical and biological properties of the binary composites were carefully studied for the first time. The bioactivities of the Fe-TCP and Zn-TCP were evaluated by simulating body fluid (SBF) immersion experiments, blood compatibility, and cytotoxicity tests. The findings demonstrated that the metal-TCP with excellent cytocompatibility and osteogenic properties shows good potential in medical applications. |
format | Online Article Text |
id | pubmed-9059545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90595452022-05-04 Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties Xie, Lu Yang, Yuanyi Fu, Zhiqiang Li, Yunfei Shi, Jiacheng Ma, Daichuan Liu, Suilin Luo, Daibing RSC Adv Chemistry Bone repairing materials play an essential role in the repair treatment of bone defects. The presence of calcium phosphate invertebrates is of significance for bone repairing processes. However, the mechanical properties and osteogenic activities of many current calcium phosphate materials are not ideal, which limit their biological applications. Therefore, it is an effective alternative strategy to study the modification of calcium phosphate biomaterials to address these limitations. In this research, in order to enhance the biological performance of tricalcium phosphate (β-TCP), metal species (Fe and Zn) modified β-TCP materials through the co-precipitation method were successfully developed. The physical, chemical and biological properties of the binary composites were carefully studied for the first time. The bioactivities of the Fe-TCP and Zn-TCP were evaluated by simulating body fluid (SBF) immersion experiments, blood compatibility, and cytotoxicity tests. The findings demonstrated that the metal-TCP with excellent cytocompatibility and osteogenic properties shows good potential in medical applications. The Royal Society of Chemistry 2019-01-07 /pmc/articles/PMC9059545/ /pubmed/35517622 http://dx.doi.org/10.1039/c8ra08453j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Xie, Lu Yang, Yuanyi Fu, Zhiqiang Li, Yunfei Shi, Jiacheng Ma, Daichuan Liu, Suilin Luo, Daibing Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title | Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title_full | Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title_fullStr | Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title_full_unstemmed | Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title_short | Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties |
title_sort | fe/zn-modified tricalcium phosphate (tcp) biomaterials: preparation and biological properties |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059545/ https://www.ncbi.nlm.nih.gov/pubmed/35517622 http://dx.doi.org/10.1039/c8ra08453j |
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