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Pituitary Apoplexy Precipitated by Systemic Chemotherapy

Pituitary apoplexy often occurs in patients with previously undiagnosed pituitary adenomas and no predisposing factors. Among patients with precipitating events, there are very few cases of pituitary apoplexy occurring in the setting of systemic chemotherapy treatment. A 31-year-old man with newly d...

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Autores principales: Hamrick, Forrest A, Findlay, Matthew C, Rennert, Robert C, Budohoski, Karol P, Couldwell, William T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059552/
https://www.ncbi.nlm.nih.gov/pubmed/35510021
http://dx.doi.org/10.7759/cureus.23004
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author Hamrick, Forrest A
Findlay, Matthew C
Rennert, Robert C
Budohoski, Karol P
Couldwell, William T
author_facet Hamrick, Forrest A
Findlay, Matthew C
Rennert, Robert C
Budohoski, Karol P
Couldwell, William T
author_sort Hamrick, Forrest A
collection PubMed
description Pituitary apoplexy often occurs in patients with previously undiagnosed pituitary adenomas and no predisposing factors. Among patients with precipitating events, there are very few cases of pituitary apoplexy occurring in the setting of systemic chemotherapy treatment. A 31-year-old man with newly diagnosed metastatic testicular cancer developed headaches, nausea, and a right-sided visual field deficit one week after initiation of bleomycin, etoposide, and cisplatin chemotherapy. Computed tomography and magnetic resonance imaging revealed hemorrhage within a pituitary macroadenoma consistent with pituitary apoplexy, and he underwent urgent transnasal resection. We also review the four prior cases of pituitary apoplexy temporally associated with the administration of systemic chemotherapy.
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spelling pubmed-90595522022-05-03 Pituitary Apoplexy Precipitated by Systemic Chemotherapy Hamrick, Forrest A Findlay, Matthew C Rennert, Robert C Budohoski, Karol P Couldwell, William T Cureus Neurosurgery Pituitary apoplexy often occurs in patients with previously undiagnosed pituitary adenomas and no predisposing factors. Among patients with precipitating events, there are very few cases of pituitary apoplexy occurring in the setting of systemic chemotherapy treatment. A 31-year-old man with newly diagnosed metastatic testicular cancer developed headaches, nausea, and a right-sided visual field deficit one week after initiation of bleomycin, etoposide, and cisplatin chemotherapy. Computed tomography and magnetic resonance imaging revealed hemorrhage within a pituitary macroadenoma consistent with pituitary apoplexy, and he underwent urgent transnasal resection. We also review the four prior cases of pituitary apoplexy temporally associated with the administration of systemic chemotherapy. Cureus 2022-03-09 /pmc/articles/PMC9059552/ /pubmed/35510021 http://dx.doi.org/10.7759/cureus.23004 Text en Copyright © 2022, Hamrick et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurosurgery
Hamrick, Forrest A
Findlay, Matthew C
Rennert, Robert C
Budohoski, Karol P
Couldwell, William T
Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title_full Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title_fullStr Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title_full_unstemmed Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title_short Pituitary Apoplexy Precipitated by Systemic Chemotherapy
title_sort pituitary apoplexy precipitated by systemic chemotherapy
topic Neurosurgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059552/
https://www.ncbi.nlm.nih.gov/pubmed/35510021
http://dx.doi.org/10.7759/cureus.23004
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