Cargando…
Base-promoted lipase-catalyzed kinetic resolution of atropisomeric 1,1′-biaryl-2,2′-diols
Herein we report a dramatic acceleration of the lipase-catalyzed kinetic resolution of atropisomeric 1,1′-biaryl-2,2′-diols by the addition of sodium carbonate. This result likely originates from the increased nucleophilicity of the phenolic hydroxyl group toward the acyl-enzyme intermediate. Under...
Autores principales: | Moustafa, Gamal A. I., Kasama, Kengo, Higashio, Koichi, Akai, Shuji |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059663/ https://www.ncbi.nlm.nih.gov/pubmed/35518007 http://dx.doi.org/10.1039/c8ra09070j |
Ejemplares similares
-
Frontier molecular orbital effects control the hole-catalyzed racemization of atropisomeric biaryls
por: Tan, Jacqueline S. J., et al.
Publicado: (2018) -
General Approach to the Synthesis of Prochiral Atropisomeric Biaryls
por: Kielar, Katarzyna, et al.
Publicado: (2011) -
Direct enantioseparation of axially chiral 1,1′-biaryl-2,2′-diols using amidine-based resolving agents
por: Kodama, Koichi, et al.
Publicado: (2021) -
Catalytic asymmetric oxo-Diels–Alder reactions with chiral atropisomeric biphenyl diols
por: Yeung, Chi-Tung, et al.
Publicado: (2019) -
Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis
por: Xiao, Xiao, et al.
Publicado: (2022)