Site-specific labeling of an anti-MUC1 antibody: probing the effects of conjugation and linker chemistry on the internalization process

Antibody-drug conjugates (ADCs) have recently received enormous attention as an attractive approach for cancer therapy. Although ADC design has been believed to be important for the relative efficacy of ADCs, it remains unexplored how the structural characteristics of ADCs would impact the internali...

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Detalles Bibliográficos
Autores principales: Xu, Hongjiao, Gan, Lu, Han, Ying, Da, Yifan, Xiong, Jiale, Hong, Sihua, Zhao, Qian, Song, Nazi, Cai, Xiaoqing, Jiang, Xianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059757/
https://www.ncbi.nlm.nih.gov/pubmed/35516120
http://dx.doi.org/10.1039/c8ra09902b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059757/
https://www.ncbi.nlm.nih.gov/pubmed/35516120
http://dx.doi.org/10.1039/c8ra09902b

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