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Enzymatic synthesis of enantiopure alcohols: current state and perspectives
Enantiomerically pure alcohols, as key intermediates, play an essential role in the pharmaceutical, agrochemical and chemical industries. Among the methods used for their production, biotechnological approaches are generally considered a green and effective alternative due to their mild reaction con...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059855/ https://www.ncbi.nlm.nih.gov/pubmed/35516160 http://dx.doi.org/10.1039/c8ra09004a |
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author | Chen, Bi-Shuang Ribeiro de Souza, Fayene Zeferino |
author_facet | Chen, Bi-Shuang Ribeiro de Souza, Fayene Zeferino |
author_sort | Chen, Bi-Shuang |
collection | PubMed |
description | Enantiomerically pure alcohols, as key intermediates, play an essential role in the pharmaceutical, agrochemical and chemical industries. Among the methods used for their production, biotechnological approaches are generally considered a green and effective alternative due to their mild reaction conditions and remarkable enantioselectivity. An increasing number of enzymatic strategies for the synthesis of these compounds has been developed over the years, among which seven primary methodologies can be distinguished as follows: (1) enantioselective water addition to alkenes, (2) enantioselective aldol addition, (3) enantioselective coupling of ketones with hydrogen cyanide, (4) asymmetric reduction of carbonyl compounds, (5) (dynamic) kinetic resolution of racemates, (6) enantioselective hydrolysis of epoxides, and (7) stereoselective hydroxylation of unactivated C–H bonds. Some recent reviews have examined these approaches separately; however, to date, no review has included all the above mentioned strategies. The aim of this mini-review is to provide an overview of all seven enzymatic strategies and draw conclusions on the effect of each approach. |
format | Online Article Text |
id | pubmed-9059855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90598552022-05-04 Enzymatic synthesis of enantiopure alcohols: current state and perspectives Chen, Bi-Shuang Ribeiro de Souza, Fayene Zeferino RSC Adv Chemistry Enantiomerically pure alcohols, as key intermediates, play an essential role in the pharmaceutical, agrochemical and chemical industries. Among the methods used for their production, biotechnological approaches are generally considered a green and effective alternative due to their mild reaction conditions and remarkable enantioselectivity. An increasing number of enzymatic strategies for the synthesis of these compounds has been developed over the years, among which seven primary methodologies can be distinguished as follows: (1) enantioselective water addition to alkenes, (2) enantioselective aldol addition, (3) enantioselective coupling of ketones with hydrogen cyanide, (4) asymmetric reduction of carbonyl compounds, (5) (dynamic) kinetic resolution of racemates, (6) enantioselective hydrolysis of epoxides, and (7) stereoselective hydroxylation of unactivated C–H bonds. Some recent reviews have examined these approaches separately; however, to date, no review has included all the above mentioned strategies. The aim of this mini-review is to provide an overview of all seven enzymatic strategies and draw conclusions on the effect of each approach. The Royal Society of Chemistry 2019-01-15 /pmc/articles/PMC9059855/ /pubmed/35516160 http://dx.doi.org/10.1039/c8ra09004a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Chen, Bi-Shuang Ribeiro de Souza, Fayene Zeferino Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title | Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title_full | Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title_fullStr | Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title_full_unstemmed | Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title_short | Enzymatic synthesis of enantiopure alcohols: current state and perspectives |
title_sort | enzymatic synthesis of enantiopure alcohols: current state and perspectives |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059855/ https://www.ncbi.nlm.nih.gov/pubmed/35516160 http://dx.doi.org/10.1039/c8ra09004a |
work_keys_str_mv | AT chenbishuang enzymaticsynthesisofenantiopurealcoholscurrentstateandperspectives AT ribeirodesouzafayenezeferino enzymaticsynthesisofenantiopurealcoholscurrentstateandperspectives |