Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19

This study was intended to define T lymphocyte subsets in different clinical groups of COVID-19-infected patients to explore the interaction between T cell-mediated immune response and the severity of COVID-19 course. Lymphopenia in patients with severe COVID-19 was found. In patients with severe CO...

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Detalles Bibliográficos
Autores principales: Zhao, C., Hu, X., Xue, Q., Chen, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059903/
https://www.ncbi.nlm.nih.gov/pubmed/35501642
http://dx.doi.org/10.1007/s10517-022-05464-9
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author Zhao, C.
Hu, X.
Xue, Q.
Chen, L.
author_facet Zhao, C.
Hu, X.
Xue, Q.
Chen, L.
author_sort Zhao, C.
collection PubMed
description This study was intended to define T lymphocyte subsets in different clinical groups of COVID-19-infected patients to explore the interaction between T cell-mediated immune response and the severity of COVID-19 course. Lymphopenia in patients with severe COVID-19 was found. In patients with severe COVID-19 course, the absolute counts of CD3(+), CD4(+), and CD8(+) T lymphocytes at admission were lower than on day 14 after discharge. Further analysis showed that the older were the patients with COVID-19, the more likely they developed severe infection. The results confirmed the significance of T lymphocytes in the clearance of the COVID-19.
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spelling pubmed-90599032022-05-03 Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19 Zhao, C. Hu, X. Xue, Q. Chen, L. Bull Exp Biol Med Article This study was intended to define T lymphocyte subsets in different clinical groups of COVID-19-infected patients to explore the interaction between T cell-mediated immune response and the severity of COVID-19 course. Lymphopenia in patients with severe COVID-19 was found. In patients with severe COVID-19 course, the absolute counts of CD3(+), CD4(+), and CD8(+) T lymphocytes at admission were lower than on day 14 after discharge. Further analysis showed that the older were the patients with COVID-19, the more likely they developed severe infection. The results confirmed the significance of T lymphocytes in the clearance of the COVID-19. Springer US 2022-05-02 2022 /pmc/articles/PMC9059903/ /pubmed/35501642 http://dx.doi.org/10.1007/s10517-022-05464-9 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Zhao, C.
Hu, X.
Xue, Q.
Chen, L.
Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title_full Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title_fullStr Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title_full_unstemmed Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title_short Reduced Counts of Various Subsets of Peripheral Blood T Lymphocytes in Patients with Severe Course of COVID-19
title_sort reduced counts of various subsets of peripheral blood t lymphocytes in patients with severe course of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059903/
https://www.ncbi.nlm.nih.gov/pubmed/35501642
http://dx.doi.org/10.1007/s10517-022-05464-9
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