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Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance
BACKGROUND: Little is known about the risk of diabetes due to higher glycemic variability and the underlying mechanisms. We aimed to examine the association of visit‐to‐visit variability (VVV) in fasting plasma glucose (FPG) with incident diabetes in Chinese adults and whether the association was me...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060060/ https://www.ncbi.nlm.nih.gov/pubmed/35170854 http://dx.doi.org/10.1111/1753-0407.13253 |
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author | Xu, Jiji Li, Ling Huang, Shuangqing Song, Haihong Gao, Jinli Ni, Hengru Lin, Hong Wang, Shuangyuan Li, Mian Wang, Tiange Zhao, Zhiyun Xu, Min Lu, Jieli Bi, Yufang Xu, Yu Qian, Xiaozhong |
author_facet | Xu, Jiji Li, Ling Huang, Shuangqing Song, Haihong Gao, Jinli Ni, Hengru Lin, Hong Wang, Shuangyuan Li, Mian Wang, Tiange Zhao, Zhiyun Xu, Min Lu, Jieli Bi, Yufang Xu, Yu Qian, Xiaozhong |
author_sort | Xu, Jiji |
collection | PubMed |
description | BACKGROUND: Little is known about the risk of diabetes due to higher glycemic variability and the underlying mechanisms. We aimed to examine the association of visit‐to‐visit variability (VVV) in fasting plasma glucose (FPG) with incident diabetes in Chinese adults and whether the association was mediated by changes in insulin resistance (IR). METHODS: We included 1856 community residents without a history of diabetes and having attended 3 examinations in 2008, 2009, and 2013 respectively. The SD, the average successive variability (ASV), the coefficient of variation (CV), and the variability independent of the mean (VIM) of three recorded FPG measurements were calculated for each participant, and SD, ASV, CV, and VIM were used as a measure of VVV in FPG. Incident diabetes was defined according to the 1999 World Health Organization criteria. IR was evaluated using the homeostatic model assessment (HOMA). RESULTS: A total of 153 (8.2%) participants developed incident diabetes at the third visit. Compared with the lowest tertile (0–5.83 mg/dl) of FPG‐SD, the highest tertile (9.55–74.17 mg/dl) was associated with a 148% increased risk of diabetes (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.36–4.49), after adjustment for covariates including mean FPG at 3 visits. Mediation analyses suggested that changes in IR (ΔHOMA‐IR) might mediate 17.3% of the association between increased FPG‐SD and elevated diabetes risk. Similar results were found for FPG‐CV, FPG‐ASV, and FPG‐VIM. CONCLUSIONS: The VVV in FPG was significantly associated with risks of diabetes in Chinese adults, which was partially mediated by changes in IR. |
format | Online Article Text |
id | pubmed-9060060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-90600602022-07-12 Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance Xu, Jiji Li, Ling Huang, Shuangqing Song, Haihong Gao, Jinli Ni, Hengru Lin, Hong Wang, Shuangyuan Li, Mian Wang, Tiange Zhao, Zhiyun Xu, Min Lu, Jieli Bi, Yufang Xu, Yu Qian, Xiaozhong J Diabetes Original Articles BACKGROUND: Little is known about the risk of diabetes due to higher glycemic variability and the underlying mechanisms. We aimed to examine the association of visit‐to‐visit variability (VVV) in fasting plasma glucose (FPG) with incident diabetes in Chinese adults and whether the association was mediated by changes in insulin resistance (IR). METHODS: We included 1856 community residents without a history of diabetes and having attended 3 examinations in 2008, 2009, and 2013 respectively. The SD, the average successive variability (ASV), the coefficient of variation (CV), and the variability independent of the mean (VIM) of three recorded FPG measurements were calculated for each participant, and SD, ASV, CV, and VIM were used as a measure of VVV in FPG. Incident diabetes was defined according to the 1999 World Health Organization criteria. IR was evaluated using the homeostatic model assessment (HOMA). RESULTS: A total of 153 (8.2%) participants developed incident diabetes at the third visit. Compared with the lowest tertile (0–5.83 mg/dl) of FPG‐SD, the highest tertile (9.55–74.17 mg/dl) was associated with a 148% increased risk of diabetes (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.36–4.49), after adjustment for covariates including mean FPG at 3 visits. Mediation analyses suggested that changes in IR (ΔHOMA‐IR) might mediate 17.3% of the association between increased FPG‐SD and elevated diabetes risk. Similar results were found for FPG‐CV, FPG‐ASV, and FPG‐VIM. CONCLUSIONS: The VVV in FPG was significantly associated with risks of diabetes in Chinese adults, which was partially mediated by changes in IR. Wiley Publishing Asia Pty Ltd 2022-02-16 /pmc/articles/PMC9060060/ /pubmed/35170854 http://dx.doi.org/10.1111/1753-0407.13253 Text en © 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Xu, Jiji Li, Ling Huang, Shuangqing Song, Haihong Gao, Jinli Ni, Hengru Lin, Hong Wang, Shuangyuan Li, Mian Wang, Tiange Zhao, Zhiyun Xu, Min Lu, Jieli Bi, Yufang Xu, Yu Qian, Xiaozhong Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title | Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title_full | Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title_fullStr | Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title_full_unstemmed | Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title_short | Impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance |
title_sort | impact of visit‐to‐visit fasting plasma glucose variability on the development of diabetes: the mediation by insulin resistance |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060060/ https://www.ncbi.nlm.nih.gov/pubmed/35170854 http://dx.doi.org/10.1111/1753-0407.13253 |
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