DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles

DMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C–H sulfurization catalyzed by PdBr(2) enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed s...

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Detalles Bibliográficos
Autores principales: Yao, Guangkai, Wang, Bing-Feng, Yang, Shuai, Zhang, Zhi-Xiang, Xu, Han-Hong, Tang, Ri-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060301/
https://www.ncbi.nlm.nih.gov/pubmed/35518944
http://dx.doi.org/10.1039/c8ra09784d
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author Yao, Guangkai
Wang, Bing-Feng
Yang, Shuai
Zhang, Zhi-Xiang
Xu, Han-Hong
Tang, Ri-Yuan
author_facet Yao, Guangkai
Wang, Bing-Feng
Yang, Shuai
Zhang, Zhi-Xiang
Xu, Han-Hong
Tang, Ri-Yuan
author_sort Yao, Guangkai
collection PubMed
description DMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C–H sulfurization catalyzed by PdBr(2) enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C–H sulfurization of two isothiocyanates.
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spelling pubmed-90603012022-05-04 DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles Yao, Guangkai Wang, Bing-Feng Yang, Shuai Zhang, Zhi-Xiang Xu, Han-Hong Tang, Ri-Yuan RSC Adv Chemistry DMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C–H sulfurization catalyzed by PdBr(2) enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C–H sulfurization of two isothiocyanates. The Royal Society of Chemistry 2019-01-25 /pmc/articles/PMC9060301/ /pubmed/35518944 http://dx.doi.org/10.1039/c8ra09784d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yao, Guangkai
Wang, Bing-Feng
Yang, Shuai
Zhang, Zhi-Xiang
Xu, Han-Hong
Tang, Ri-Yuan
DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title_full DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title_fullStr DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title_full_unstemmed DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title_short DMSO-mediated palladium-catalyzed cyclization of two isothiocyanates via C–H sulfurization: a new route to 2-aminobenzothiazoles
title_sort dmso-mediated palladium-catalyzed cyclization of two isothiocyanates via c–h sulfurization: a new route to 2-aminobenzothiazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060301/
https://www.ncbi.nlm.nih.gov/pubmed/35518944
http://dx.doi.org/10.1039/c8ra09784d
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