Cargando…

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and global metabolism are largely unknown. Here we applied...

Descripción completa

Detalles Bibliográficos
Autores principales:	Senko, Anna N., Overall, Rupert W., Silhavy, Jan, Mlejnek, Petr, Malínská, Hana, Hüttl, Martina, Marková, Irena, Fabel, Klaus S., Lu, Lu, Stuchlik, Ales, Williams, Robert W., Pravenec, Michal, Kempermann, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060359/ https://www.ncbi.nlm.nih.gov/pubmed/35377872 http://dx.doi.org/10.1371/journal.pgen.1009638

Ejemplares similares

Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel
por: Simonis, Marieke, et al.
Publicado: (2012)

Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel
por: Lusk, Ryan, et al.
Publicado: (2022)

CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
por: Silhavy, Jan, et al.
Publicado: (2023)

Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats
por: Šilhavý, Jan, et al.
Publicado: (2020)

Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
por: Malínská, Hana, et al.
Publicado: (2022)

Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome
por: Šilhavý, Jan, et al.
Publicado: (2023)

The Small World of Adult Hippocampal Neurogenesis
por: Overall, Rupert W., et al.
Publicado: (2018)

Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
por: Hüttl, Martina, et al.
Publicado: (2023)

The Mammalian Adult Neurogenesis Gene Ontology (MANGO) Provides a Structural Framework for Published Information on Genes Regulating Adult Hippocampal Neurogenesis
por: Overall, Rupert W., et al.
Publicado: (2012)

Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene
por: Krebs, Julia, et al.
Publicado: (2011)

Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity
por: Römer, Benedikt, et al.
Publicado: (2011)

Delayed and Transient Increase of Adult Hippocampal Neurogenesis by Physical Exercise in DBA/2 Mice
por: Overall, Rupert W., et al.
Publicado: (2013)

Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation
por: Junková, Kristýna, et al.
Publicado: (2021)

Dynamic learning and memory, synaptic plasticity and neurogenesis: an update
por: Stuchlik, Ales
Publicado: (2014)

Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
por: Malínská, Hana, et al.
Publicado: (2016)

Complete Genome Sequence of Riemerella anatipestifer Serotype 10 Strain HXb2
por: Hu, Qinghai, et al.
Publicado: (2017)

Additive Effects of Physical Exercise and Environmental Enrichment on Adult Hippocampal Neurogenesis in Mice
por: Fabel, Klaus, et al.
Publicado: (2009)

Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
por: Šilhavý, Jan, et al.
Publicado: (2022)

Tis21 Expression Marks Not Only Populations of Neurogenic Precursor Cells but Also New Postmitotic Neurons in Adult Hippocampal Neurogenesis
por: Attardo, Alessio, et al.
Publicado: (2010)

Ranska pid tti ydintutkijan terroristiyhteyksien takia
Publicado: (2009)

Prevalence of TTI among Indian blood donors
por: Thakur, Sanjay Kumar, et al.
Publicado: (2023)

Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells
por: Walker, Tara L., et al.
Publicado: (2016)

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone
por: Pal, Mohinder, et al.
Publicado: (2021)

TTT (Tel2-Tti1-Tti2) Complex, the Co-Chaperone of PIKKs and a Potential Target for Cancer Chemotherapy
por: Bhadra, Sankhadip, et al.
Publicado: (2023)

Oppositional Effects of Serotonin Receptors 5-HT1a, 2, and 2c in the Regulation of Adult Hippocampal Neurogenesis
por: Klempin, Friederike, et al.
Publicado: (2010)

The Different Insulin-Sensitising and Anti-Inflammatory Effects of Palmitoleic Acid and Oleic Acid in a Prediabetes Model
por: Miklankova, Denisa, et al.
Publicado: (2022)

Chemiluminescence brings renaissance in TTI screening: Primi experientia
por: Rout, Diptiranjan, et al.
Publicado: (2017)

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis
por: Zocher, Sara, et al.
Publicado: (2021)

A role of TTI1 in the colorectal cancer by promoting proliferation
por: Xu, Peng, et al.
Publicado: (2021)

Adult neurogenesis : stem cells and neuronal development in the adult brain /
por: Kempermann, Gerd
Publicado: (2006)

Workshop Report: Systems Genetics of Neurodegenerative Disease, a Summer School in Systems Medicine, 25th August−1st September 2017
por: Overall, Rupert W., et al.
Publicado: (2019)

Metformin Affects Cardiac Arachidonic Acid Metabolism and Cardiac Lipid Metabolite Storage in a Prediabetic Rat Model
por: Miklankova, Denisa, et al.
Publicado: (2021)

Quercetin supplementation alters adipose tissue and hepatic transcriptomes and ameliorates adiposity, dyslipidemia, and glucose intolerance in adult male rats
por: Kábelová, Adéla, et al.
Publicado: (2022)

What Is Adult Hippocampal Neurogenesis Good for?
por: Kempermann, Gerd
Publicado: (2022)

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response
por: Hoffman, Kyle S., et al.
Publicado: (2016)

Development of the adult neurogenic niche in the hippocampus of mice
por: Nicola, Zeina, et al.
Publicado: (2015)

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus
por: Zocher, Sara, et al.
Publicado: (2021)

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
por: Pons-Espinal, Meritxell, et al.
Publicado: (2019)

Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia
por: Malinská, Hana, et al.
Publicado: (2021)

Cardiovascular, Metabolic and Inflammatory Changes after Ovariectomy and Estradiol Substitution in Hereditary Hypertriglyceridemic Rats
por: Pitha, Jan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kt96sfcrk1mvo6dc9c7p8q2mt8