Cargando…

Predicting the functional impact of KCNQ1 variants with artificial neural networks

Recent advances in experimental and computational protein structure determination have provided access to high-quality structures for most human proteins and mutants thereof. However, linking changes in structure in protein mutants to functional impact remains an active area of method development. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phul, Saksham, Kuenze, Georg, Vanoye, Carlos G., Sanders, Charles R., George, Alfred L., Meiler, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060377/ https://www.ncbi.nlm.nih.gov/pubmed/35442947 http://dx.doi.org/10.1371/journal.pcbi.1010038

Ejemplares similares

Upgraded molecular models of the human KCNQ1 potassium channel
por: Kuenze, Georg, et al.
Publicado: (2019)

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation
por: Kuenze, Georg, et al.
Publicado: (2020)

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations
por: Huang, Hui, et al.
Publicado: (2018)

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome
por: Brewer, Kathryn R., et al.
Publicado: (2020)

Disease-linked supertrafficking of a potassium channel
por: Huang, Hui, et al.
Publicado: (2021)

Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1
por: Kroncke, Brett M., et al.
Publicado: (2019)

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state
por: Taylor, Keenan C, et al.
Publicado: (2020)

Personalized Biochemistry and Biophysics
por: Kroncke, Brett M., et al.
Publicado: (2015)

Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits
por: Vanoye, Carlos G., et al.
Publicado: (2009)

High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity
por: Vanoye, Carlos G., et al.
Publicado: (2022)

An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization
por: Chen, Zhuyuan, et al.
Publicado: (2021)

Docking cholesterol to integral membrane proteins with Rosetta
por: Marlow, Brennica, et al.
Publicado: (2023)

Purification and Structural Study of the Voltage-Sensor Domain of the Human KCNQ1 Potassium Ion Channel
por: Peng, Dungeng, et al.
Publicado: (2014)

The Pathological Mechanisms of Hearing Loss Caused by KCNQ1 and KCNQ4 Variants
por: Homma, Kazuaki
Publicado: (2022)

Clinical Study of 30 Novel KCNQ2 Variants/Deletions in KCNQ2-Related Disorders
por: Xiao, Tiantian, et al.
Publicado: (2022)

Dyshomeostatic modulation of Ca(2+)-activated K(+) channels in a human neuronal model of KCNQ2 encephalopathy
por: Simkin, Dina, et al.
Publicado: (2021)

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
por: Soh, Heun, et al.
Publicado: (2022)

Behavior of KCNQ Channels in Neural Plasticity and Motor Disorders
por: Singh, Som P., et al.
Publicado: (2022)

Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy
por: Calhoun, Jeffrey D., et al.
Publicado: (2017)

Overlooked KCNQ4 variants augment the risk of hearing loss
por: Oh, Kyung Seok, et al.
Publicado: (2023)

Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy
por: Gertler, Tracy S., et al.
Publicado: (2019)

Artificial Neural Networks for Prediction of Tuberculosis Disease
por: Khan, Muhammad Tahir, et al.
Publicado: (2019)

Co‐crystal Prediction by Artificial Neural Networks
por: Devogelaer, Jan‐Joris, et al.
Publicado: (2020)

Application of artificial neural network in predicting EI
por: Allahyari, Elahe
Publicado: (2020)

Artificial Neural Networks for the Prediction of Monkeypox Outbreak
por: Manohar, Balakrishnama, et al.
Publicado: (2022)

Clinically Relevant KCNQ1 Variants Causing KCNQ1-KCNE2 Gain-of-Function Affect the Ca(2+) Sensitivity of the Channel
por: Bauer, Christiane K., et al.
Publicado: (2022)

Structural basis for KCNE3 modulation of potassium recycling in epithelia
por: Kroncke, Brett M., et al.
Publicado: (2016)

Mouse models of Kcnq2 dysfunction
por: Brun, Lucile, et al.
Publicado: (2022)

A novel variant in KCNQ1 associated with short QT syndrome
por: Schneider, Kristin, et al.
Publicado: (2021)

Artificial neural networks for engineering applications
por: Alanis, Alma Y, et al.
Publicado: (2019)

Artificial neural networks
por: Cain, Gayle
Publicado: (2016)

Artificial neural network applications for software reliability prediction
por: Bisi, Manjubala, et al.
Publicado: (2017)

Artificial neural networks as prediction tools in the critically ill
por: Clermont, Gilles
Publicado: (2005)

Artificial neural network in predicting bladder cancer recurrence
por: Borkowska, Edyta, et al.
Publicado: (2012)

The Use of Artificial Neural Network for Prediction of Dissolution Kinetics
por: Elçiçek, H., et al.
Publicado: (2014)

Prediction of perioperative transfusions using an artificial neural network
por: Walczak, Steven, et al.
Publicado: (2020)

Predicting mental health of prisoners by artificial neural network
por: Allahyari, Elahe, et al.
Publicado: (2021)

Pancreatic Cancer Prediction Through an Artificial Neural Network
por: Muhammad, Wazir, et al.
Publicado: (2019)

Promoter prediction in E. coli based on SIDD profiles and Artificial Neural Networks
por: Bland, Charles, et al.
Publicado: (2010)

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes
por: Wang, Yundi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_743qe3pdluklm68ckrpuklvhfe