Cargando…
Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins
The polytheonamides are highly modified and potent, cytotoxic peptides with a unique β-helical structure (helical diameter ∼4 Å) that affords selective membrane permeation of monovalent cations. Toxicity has been linked to promiscuous ion-channel behavior in studies of the prototypical polytheonamid...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060474/ https://www.ncbi.nlm.nih.gov/pubmed/35316135 http://dx.doi.org/10.1073/pnas.2116578119 |