Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS

Connexin 43 (Cx43) gap junctions and hemichannels mediate astrocyte intercellular communication in the central nervous system under normal conditions and contribute to astrocyte-mediated neurotoxicity in amyotrophic lateral sclerosis (ALS). Here, we show that astrocyte-specific knockout of Cx43 in a...

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Detalles Bibliográficos
Autores principales: Almad, Akshata A., Taga, Arens, Joseph, Jessica, Gross, Sarah K., Welsh, Connor, Patankar, Aneesh, Richard, Jean-Philippe, Rust, Khalil, Pokharel, Aayush, Plott, Caroline, Lillo, Mauricio, Dastgheyb, Raha, Eggan, Kevin, Haughey, Norman, Contreras, Jorge E., Maragakis, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060483/
https://www.ncbi.nlm.nih.gov/pubmed/35312356
http://dx.doi.org/10.1073/pnas.2107391119

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