Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action

BACKGROUND: Leishmania parasites cause leishmaniasis that range from self-limiting cutaneous lesions to more serious forms of the disease. The search for potential drug targets focusing on biochemical and metabolic pathways revealed the sterol biosynthesis inhibitors (SBIs) as a promising approach....

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Detalles Bibliográficos
Autores principales: Nunes, Débora Cristina de Oliveira Silva, Costa, Mônica Soares, Bispo-da-Silva, Luiz Borges, Ferro, Eloísa Amália Vieira, Zóia, Mariana Alves Pereira, Goulart, Luiz Ricardo, Rodrigues, Renata Santos, Rodrigues, Veridiana de Melo, Yoneyama, Kelly Aparecida Geraldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060495/
https://www.ncbi.nlm.nih.gov/pubmed/35508030
http://dx.doi.org/10.1590/0074-02760210157

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