A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

The iron-containing heterodimeric MbnBC enzyme complex plays a central role in the biosynthesis of methanobactins (Mbns), ribosomally synthesized, posttranslationally modified natural products that bind copper with high affinity. MbnBC catalyzes a four-electron oxidation of a cysteine residue in its...

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Detalles Bibliográficos
Autores principales: Park, Yun Ji, Jodts, Richard J., Slater, Jeffrey W., Reyes, Reyvin M., Winton, Valerie J., Montaser, Rana A., Thomas, Paul M., Dowdle, William B., Ruiz, Anahi, Kelleher, Neil L., Bollinger, J. Martin, Krebs, Carsten, Hoffman, Brian M., Rosenzweig, Amy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060507/
https://www.ncbi.nlm.nih.gov/pubmed/35320042
http://dx.doi.org/10.1073/pnas.2123566119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060507/
https://www.ncbi.nlm.nih.gov/pubmed/35320042
http://dx.doi.org/10.1073/pnas.2123566119

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