Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

BACKGROUND: Natural killer (NK) cells are innate lymphoid cells that mediate antitumour and antiviral responses. However, very little is known about how ageing influences human NK cells, especially at the single-cell level. METHODS: We applied single-cell sequencing (scRNA-seq) to human lymphocytes...

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Detalles Bibliográficos
Autores principales: Guo, Chuang, Wu, Mingming, Huang, Beibei, Zhao, Rui, Jin, Linlin, Fu, Binqing, Wang, Ping, Wang, Dongyao, Zheng, Meijuan, Fang, Jingwen, Wei, Haiming, Qu, Kun, Ni, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060844/
https://www.ncbi.nlm.nih.gov/pubmed/35501841
http://dx.doi.org/10.1186/s13073-022-01049-3

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