Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

Detalles Bibliográficos
Autores principales: Aksenov, Alexander V., Khamraev, Vladislav, Aksenov, Nicolai A., Kirilov, Nikita K., Domenyuk, Dmitriy A., Zelensky, Vladimir A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060929/
https://www.ncbi.nlm.nih.gov/pubmed/35518500
http://dx.doi.org/10.1039/c9ra00976k
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author Aksenov, Alexander V.
Khamraev, Vladislav
Aksenov, Nicolai A.
Kirilov, Nikita K.
Domenyuk, Dmitriy A.
Zelensky, Vladimir A.
Rubin, Michael
author_facet Aksenov, Alexander V.
Khamraev, Vladislav
Aksenov, Nicolai A.
Kirilov, Nikita K.
Domenyuk, Dmitriy A.
Zelensky, Vladimir A.
Rubin, Michael
author_sort Aksenov, Alexander V.
collection PubMed
description A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.
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spelling pubmed-90609292022-05-04 Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles Aksenov, Alexander V. Khamraev, Vladislav Aksenov, Nicolai A. Kirilov, Nikita K. Domenyuk, Dmitriy A. Zelensky, Vladimir A. Rubin, Michael RSC Adv Chemistry A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides. The Royal Society of Chemistry 2019-02-26 /pmc/articles/PMC9060929/ /pubmed/35518500 http://dx.doi.org/10.1039/c9ra00976k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Aksenov, Alexander V.
Khamraev, Vladislav
Aksenov, Nicolai A.
Kirilov, Nikita K.
Domenyuk, Dmitriy A.
Zelensky, Vladimir A.
Rubin, Michael
Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title_full Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title_fullStr Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title_full_unstemmed Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title_short Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
title_sort electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060929/
https://www.ncbi.nlm.nih.gov/pubmed/35518500
http://dx.doi.org/10.1039/c9ra00976k
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