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Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

Detalles Bibliográficos
Autores principales:	Aksenov, Alexander V., Khamraev, Vladislav, Aksenov, Nicolai A., Kirilov, Nikita K., Domenyuk, Dmitriy A., Zelensky, Vladimir A., Rubin, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060929/ https://www.ncbi.nlm.nih.gov/pubmed/35518500 http://dx.doi.org/10.1039/c9ra00976k

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