MiR-9-5p Inhibits the MMP(+)-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson's Disease

The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminerg...

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Detalles Bibliográficos
Autores principales: Xiao, Zhenyong, Yan, Zhenxing, Sun, Xiang, Zhu, Zhiyuan, Wang, Baoyan, Gao, Mengqi, Lu, Fengfei, Liu, Jian, Zong, Zhitao, Zhang, Hongbo, Guo, Yanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060974/
https://www.ncbi.nlm.nih.gov/pubmed/35509839
http://dx.doi.org/10.1155/2022/9173514
Descripción
Sumario:The pathogenesis of Parkinson's disease remains unclear that there is no cure for Parkinson's disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson's disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson's disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson's disease.

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